With disulfiramom reported on the development of psychotic reactions in patients treated with both metronidazole and disulfiram (the interval between administration of metronidazole should be at least 2 weeks). With ethanol may experience difulfiramopodobnyh reactions (redness of the skin, vomiting, tachycardia). with indirect anticoagulants (warfarin)Strengthening of the anticoagulant effect and increase the hemorrhagic risk associated with a slowing of their hepatic metabolism, which can lead to an increase in prothrombin time. In the event of simultaneous applications require more frequent monitoring of prothrombin time and, if necessary, dose adjustment of anticoagulants.
With methenolone enanthate lithium preparations , when taken concomitantly with metronidazole drugs lithium may increase the concentration of the latter in the blood plasma. In an application should be monitored plasma concentrations of lithium, creatinine and electrolytes. With cyclosporine At simultaneous reception of metronidazole with cyclosporine may increase the serum concentration of cyclosporine. If necessary, the simultaneous use of these two metronidazole requires monitoring serum cyclosporine and creatinine. With cimetidine, cimetidine inhibits metabolism metronidazole, which may lead to an increase in its concentration in the serum and an increased risk of side effects. Since drugs that induce enzymes of microsomal oxidation in the liver (phenobarbital, phenytoin) Simultaneous administration of metronidazole with drugs stimulating enzymes microsomal oxidation in the liver (phenobarbital, phenytoin) may accelerate the elimination of metronidazole, thereby reducing its concentration in plasma. with fluorouracil metronidazole reduces clearance fluorouracil, resulting in increased toxicity. since busulfan metronidazole increases the concentration of busulfan in the plasma, which may lead to the development of severe toxic effect of busulfan. with the non-depolarizing muscle relaxants (vecuronium bromide) is not recommended to be combined with non-depolarizing muscle relaxants (vecuronium bromide). Sulfonamide enhance the antimicrobial action of metronidazole.
Precautions for use of the drug
As the concomitant use of metronidazole with alcohol can have an effect similar to disulfiram (burning sensation, vomiting, tachycardia), should warn patients that during Flagyl drug methenolone enanthate should not drink alcohol or medicines that contain alcohol .
it is necessary to carefully weigh the evidence for long-term use of the drug and without strict indications avoid its prolonged use. Where there are strict indications preparation is applied over a long time, what is usually recommended, treatment should be under the control of haematological parameters and side reactions such as peripheral or central neuropathy (paresthesias, ataxia, dizziness, convulsions), when they appear, treatment should be discontinued .
in the treatment vaginitis in womenurethritis in men should refrain from sexual activity. Be sure to simultaneous treatment of sexual partners. Treatment does not stop at the time of menstruation. After treatment of trichomoniasis should conduct pilot tests for 3 successive cycles before and after menstruation.
It is necessary to take into account may immobilize , which leads to false positive test Nelson.
Effects on ability to drive and occupation of other potentially hazardous activities
Taking methenolone enanthate into account the profile of side effects (dizziness, blurred vision, etc.) are advised to refrain from driving, lessons from other potentially hazardous activities that require high concentration and psychomotor speed reactions.