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primobolan side effects

In intramuscular a time to maximum plasma concentration is 15-30 minutes. Bioavailability – 90%. Associated primobolan side effects with the plasma protein by 99%. The equilibrium concentration in plasma is achieved at 24 hours after initiation of regular use. Therapeutic concentrations in the synovial fluid is maintained for 6-8 hours. It is metabolized in the liver by glyukuronirovaniya. It is shown mainly by the kidneys and intestines by 1-8%. The half-life is 1.6 – 1.9 hours, not accumulates..

 

Indications for use:

Short-term symptomatic treatment of acute pain in inflammatory processes of various origins: osteoarthritis, ankylosing spondylitis, gouty arthritis, acute gout, rheumatoid arthritis, psoriatic arthritis; bursitis, tenosynovitis; sciatica, myalgia, neuralgia, dorsalgia, sciatica; injuries and muscle strain; adnexitis, otitis media;headache and toothache; pain syndrome in oncology; post-traumatic and postoperative pain; algomenorrhea.

 

Contraindications:

 

  • individual hypersensitivity to ketoprofen, aspirin (including specifying a history of bronchospasm, urticaria or rhinitis caused by the intake of acetylsalicylic acid);
  • gastrointestinal disease in the acute phase;
  • gastrointestinal bleeding and perforation in history;
  • The expressed disturbances of function of kidneys and liver;
  • blood disorders (leucopenia, thrombocytopenia, blood coagulation disorders, hemophilia);
  • relief of pain immediately before or immediately after surgical treatment of cardiovascular system;
  • severe heart failure;
  • pregnancy and lactation;
  • children’s age (18 years).Precautions:
    Caution is advised to use the drug in patients: with impaired liver and / or kidney disease, gastrointestinal diseases in history; asthma, rhinitis, urticaria, polyps of the nasal mucosa; hypertension and / or cardiovascular disease, cerebrovascular disease; blood diseases, anemia; alcoholism, alcoholic liver cirrhosis, hyperbilirubinemia, diabetes, dehydration, smoking, sepsis, and in older patients. 

    Dosage and administration:

    The lyophilizate is dissolved attached solvent and the resulting solution was injected deep into the muscle. Intramuscular injection is indicated for the relief of acute pain, 100 mg 1-2 times a day. Duration of the parenteral treatment usually short-lived and is several days. After reaching the desired effect to the patient is prescribed capsules or suppositories.
    The maximum daily dose should not exceed 300 mg.

    Side effects:
    From the digestive system: primobolan side effects, abdominal pain, dyspepsia (nausea, vomiting, heartburn, flatulence, loss of appetite, diarrhea), stomatitis; change in taste, ulceration, and perforation of the mucous membrane of the gastrointestinal tract, gingival, gastrointestinal, hemorrhoidal bleeding; increased activity of “liver” transaminases serum hepatitis.
    Nervous system: headache, dizziness, insomnia, agitation, nervousness, somnolence, depression, fatigue, confusion or loss of consciousness, forgetfulness, migraines, peripheral neuropathy.
    From the senses : noise or ringing in the ears, blurred vision, conjunctivitis, mucosal dryness of the eye, eye pain, conjunctival hyperemia, hearing loss, vertigo.
    cardio-vascular system: increased blood pressure, tachycardia.
    From the side of hematopoiesis: rarely – agranulocytosis , anemia, hemolytic anemia, thrombocytopenia, leukopenia.
    From the urinary system: edema syndrome, cystitis, urethritis, renal failure, interstitial nephritis, nephrotic syndrome, hematuria.
    On the part of the respiratory system: dyspnea, bronchospasm, rhinitis, laryngeal edema, epistaxis , coughing up blood, shortness of breath.
    With the skin: alopecia, eczema, erythema multiforme exudative, including Stevens-Johnson syndrome, toxic epidermal necrolysis (Lyell’s syndrome), fotodermatit.
    Allergic reactions: skin rash (including erythematous, urticaria), itching, angioedema, exfoliative dermatitis, anaphylactic shock.
    Other: increased primobolan side effects sweating, myalgia, muscle twitching, thirst, vaginal bleeding, pain and redness at the injection site.

     

    Overdose:

    Symptoms: may cause drowsiness, nausea, vomiting, abdominal pain, bleeding, liver dysfunction and kidneys.
    Treatment is symptomatic: There is no specific antidote.