Reduces the effectiveness of uricosuric drugs, increases the effects of anticoagulants, antiplatelet agents, fibrinolytic agents, ethanol, and the side effects of glucocorticosteroids mineralokortikosteroidov, estrogen; reduces the effectiveness of antihypertensive drugs and diuretics.
The joint reception with others. Primobolan dosage, corticosteroids, ethanol, corticotropin may lead to ulceration and the development of gastro-intestinal bleeding, an increase in the risk of impairment of renal function.
Co-administration with oral anticoagulants, heparin, thrombolytics, antiplatelet, cefoperazone, cefamandole and tsefotetanom increases the risk of bleeding.
It increases the hypoglycemic effect of insulin and oral hypoglycemic drugs (requires recalculation of the dose).
Inductors microsomal oxidation in the liver (phenytoin, ethanol, barbiturates, rifampicin, phenylbutazone, tricyclic antidepressants) increase the production of hydroxylated active metabolites.
Co-administration with sodium valproate causes a disturbance of platelet aggregation.
Increases plasma concentration of nifedipine and verapamil, lithium, drugs, methotrexate.
antacids and cholestyramine reduce the absorption.
Myelotoxic drugs increase the expression gematotoksichnosti drug.
pharmaceutical incompatible with a solution of tramadol.
With simultaneous use of ketoprofen and warfarin and coumarin anticoagulants or lithium salts patients should be under the strict supervision of a physician.
Caution should be exercised when administering the drug to patients with ulcerative diseases of the gastrointestinal tract in history, renal and hepatic insufficiency. During treatment necessary to monitor patterns of peripheral blood and functional state of the liver and kidneys. In violation of renal and hepatic function need to decrease the dose and careful medical supervision.
If necessary, the definition of primobolan dosage steroids drug should be discontinued 48 hours before the test.
Avoid taking alcoholic drinks!
With the development of violations the organs of vision should consult an ophthalmologist.
In the period of treatment must be careful when driving vehicles and occupation of other potentially hazardous activities that require high concentration and psychomotor speed reactions.
Valium for drug of a solution for intramuscular injection. At 100 mg drug in vials of dark glass type 1 with rings to be broken off.
A solution of benzyl primobolan dosage (solvent). 2.5 ml colorless glass vials of neutral glass of type 1 with rings to be broken off.
At 6 lyophilisate ampoules and vials with the solvent 6 for intramuscular administration of 2.5 ml, packed in a one or two plastic pallet, together with instructions for use in carton.