Approximately 20% of applied dose of metronidazole was subjected to systemic absorption, resulting in drug concentration in plasma is approximately 12% of that after oral administration of a single dose of 0.5 The primobolan results (elimination set when administered systemically at normal liver function) is 8-10 hours.Communication with plasma proteins – less than 20%.
Topical treatment vaginitis and nonspecific.
Prevention of occurrence of anaerobic infections in surgical interventions on the abdominal and pelvic organs.
- Hypersensitivity to imidazoles and nitroimidazole derivatives;
- organic (including epilepsy);
- blood diseases (including leukopenia history);
- hepatic insufficiency (in the case of the appointment of high doses);
- breast-feeding.Dosing and Administration
The drug is only used in adults. Adults
- Trichomonas vaginitis: one suppository daily, in the vagina for 10 days in combination with taking metronidazole formulation into tablets.
- Nonspecific vaginitis: 1 suppository 2 times a day for 7 days, optionally in combination with metronidazole reception formulation into tablets. Be sure to simultaneous treatment of sexual partner drug metronidazole, no matter if they have any symptoms of the disease.
Treatment with metronidazole should not be appointed for more than 10 days, and recur more often primobolan results than 2-3 times a year.
Pre-releasing suppository by using a contour packaging scissors to cut the tape along the contour of a suppository and put it deep into the vagina.Side effect On the part of the gastrointestinal tract: nausea, a metallic taste in the mouth, dry mouth, decreased appetite, glossitis, stomatitis, pancreatitis, anorexia, epigastric pain, vomiting, diarrhea, constipation. From the nervous system: headache, dizziness , incoordination, ataxia, confusion, irritability, depression, irritability, fatigue, insomnia, seizures, confusion, hallucinations, peripheral neuropathy (especially long-term use). Allergic reactions: urticaria, skin rash, redness of the skin, nasal congestion , fever, arthralgia. from the mochevydelitelyyuy system: dysuria, polyuria, cystitis, urinary incontinence, candidiasis, possibly staining of urine brownish-reddish color. Local reactions: burning sensation or irritation of the penis in the sexual partner, a burning sensation or frequent urination, vulvitis (itching, burning pain, or redness of the mucous membrane in the external genitalia). Other: neutropenia, leukopenia, flattening of the T wave on the ECG. After discontinuation of the drug may develop vaginal candidiasis.
Interaction with other drugs
similar disulfiram causes intolerance of ethanol.
Concomitant use with disulfiram may lead to the development of a variety of neurological symptoms (interval between administration – not less than 2 weeks). It enhances the effect of indirect anticoagulants, which leads to an increase in the time of formation of prothrombin.
When concomitantly with drugs lithium may increase the concentration of the latter in plasma.
When concomitantly with cyclosporine may increase the concentration of the latter in plasma.
Cimetidine inhibits the metabolism of metronidazole, which may lead to an increase in its concentration serum and an increased risk of side effects. Simultaneous administration of drugs that stimulate the microsomal oxidation enzymes in the liver (phenobarbital, phenytoin), elimination can yckoryat metronidazole, whereby its concentration decreases in plasma. Metronidazole reduces the clearance , resulting in an increase of its toxicity. Metronidazole increases the level of busulfan in plasma, resulting in an increase of its toxicity (severe).
Do not combine with non-depolarizing muscle relaxants (vecuronium bromide).
Since the simultaneous reception of alcohol-drug can have an effect similar to disulfiram (burning sensation, vomiting, tachycardia), should warn patients that during treatment flagyl should not drink alcoholic beverages or medicines containing alcohol.
Long-term administration of the drug, it is desirable be under the control of blood formula. When leukopenia opportunity to continue treatment depends on the risk of infection.
In the treatment of Trichomonas vaginitis in women should refrain from sexual activity. Be sure to simultaneous treatment of sexual partners. Treatment does not stop at the time of menstruation. After primobolan results treatment of trichomoniasis should conduct pilot tests for 3 successive cycles before and after menstruation.
It should stop treatment with the appearance of ataxia, dizziness, hallucinations development, with a deterioration in neurological status of the patients. It will be appreciated that Metronidazole may immobilize Treponema, which leads to false positive test Nelson.
Effects on ability to drive and use other mechanisms
in connection with the possibility of dizziness and other side effects associated with the reception of the drug are advised to refrain from driving and other mechanisms.