In intramuscular a time to maximum plasma concentration is 15-30 minutes. Bioavailability – 90%. Associated primobolan side effects with the plasma protein by 99%. The equilibrium concentration in plasma is achieved at 24 hours after initiation of regular use. Therapeutic concentrations in the synovial fluid is maintained for 6-8 hours. It is metabolized in the liver by glyukuronirovaniya. It is shown mainly by the kidneys and intestines by 1-8%. The half-life is 1.6 – 1.9 hours, not accumulates..
Indications for use:
Short-term symptomatic treatment of acute pain in inflammatory processes of various origins: osteoarthritis, ankylosing spondylitis, gouty arthritis, acute gout, rheumatoid arthritis, psoriatic arthritis; bursitis, tenosynovitis; sciatica, myalgia, neuralgia, dorsalgia, sciatica; injuries and muscle strain; adnexitis, otitis media;headache and toothache; pain syndrome in oncology; post-traumatic and postoperative pain; algomenorrhea.
- individual hypersensitivity to ketoprofen, aspirin (including specifying a history of bronchospasm, urticaria or rhinitis caused by the intake of acetylsalicylic acid);
- gastrointestinal disease in the acute phase;
- gastrointestinal bleeding and perforation in history;
- The expressed disturbances of function of kidneys and liver;
- blood disorders (leucopenia, thrombocytopenia, blood coagulation disorders, hemophilia);
- relief of pain immediately before or immediately after surgical treatment of cardiovascular system;
- severe heart failure;
- pregnancy and lactation;
- children’s age (18 years).Precautions:
Caution is advised to use the drug in patients: with impaired liver and / or kidney disease, gastrointestinal diseases in history; asthma, rhinitis, urticaria, polyps of the nasal mucosa; hypertension and / or cardiovascular disease, cerebrovascular disease; blood diseases, anemia; alcoholism, alcoholic liver cirrhosis, hyperbilirubinemia, diabetes, dehydration, smoking, sepsis, and in older patients.
Dosage and administration:
The lyophilizate is dissolved attached solvent and the resulting solution was injected deep into the muscle. Intramuscular injection is indicated for the relief of acute pain, 100 mg 1-2 times a day. Duration of the parenteral treatment usually short-lived and is several days. After reaching the desired effect to the patient is prescribed capsules or suppositories.
The maximum daily dose should not exceed 300 mg.
From the digestive system: primobolan side effects, abdominal pain, dyspepsia (nausea, vomiting, heartburn, flatulence, loss of appetite, diarrhea), stomatitis; change in taste, ulceration, and perforation of the mucous membrane of the gastrointestinal tract, gingival, gastrointestinal, hemorrhoidal bleeding; increased activity of “liver” transaminases serum hepatitis.
Nervous system: headache, dizziness, insomnia, agitation, nervousness, somnolence, depression, fatigue, confusion or loss of consciousness, forgetfulness, migraines, peripheral neuropathy.
From the senses : noise or ringing in the ears, blurred vision, conjunctivitis, mucosal dryness of the eye, eye pain, conjunctival hyperemia, hearing loss, vertigo.
cardio-vascular system: increased blood pressure, tachycardia.
From the side of hematopoiesis: rarely – agranulocytosis , anemia, hemolytic anemia, thrombocytopenia, leukopenia.
From the urinary system: edema syndrome, cystitis, urethritis, renal failure, interstitial nephritis, nephrotic syndrome, hematuria.
On the part of the respiratory system: dyspnea, bronchospasm, rhinitis, laryngeal edema, epistaxis , coughing up blood, shortness of breath.
With the skin: alopecia, eczema, erythema multiforme exudative, including Stevens-Johnson syndrome, toxic epidermal necrolysis (Lyell’s syndrome), fotodermatit.
Allergic reactions: skin rash (including erythematous, urticaria), itching, angioedema, exfoliative dermatitis, anaphylactic shock.
Other: increased primobolan side effects sweating, myalgia, muscle twitching, thirst, vaginal bleeding, pain and redness at the injection site.
Symptoms: may cause drowsiness, nausea, vomiting, abdominal pain, bleeding, liver dysfunction and kidneys.
Treatment is symptomatic: There is no specific antidote.