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5939

primobolan dosage

Reduces the effectiveness of uricosuric drugs, increases the effects of anticoagulants, antiplatelet agents, fibrinolytic agents, ethanol, and the side effects of glucocorticosteroids mineralokortikosteroidov, estrogen; reduces the effectiveness of antihypertensive drugs and diuretics.
The joint reception with others. Primobolan dosage, corticosteroids, ethanol, corticotropin may lead to ulceration and the development of gastro-intestinal bleeding, an increase in the risk of impairment of renal function.
Co-administration with oral anticoagulants, heparin, thrombolytics, antiplatelet, cefoperazone, cefamandole and tsefotetanom increases the risk of bleeding.
It increases the hypoglycemic effect of insulin and oral hypoglycemic drugs (requires recalculation of the dose).
Inductors microsomal oxidation in the liver (phenytoin, ethanol, barbiturates, rifampicin, phenylbutazone, tricyclic antidepressants) increase the production of hydroxylated active metabolites.
Co-administration with sodium valproate causes a disturbance of platelet aggregation.
Increases plasma concentration of nifedipine and verapamil, lithium, drugs, methotrexate.
antacids and cholestyramine reduce the absorption.
Myelotoxic drugs increase the expression gematotoksichnosti drug.
pharmaceutical incompatible with a solution of tramadol.

 

Special instructions:

With simultaneous use of ketoprofen and warfarin and coumarin anticoagulants or lithium salts patients should be under the strict supervision of a physician.
Caution should be exercised when administering the drug to patients with ulcerative diseases of the gastrointestinal tract in history, renal and hepatic insufficiency. During treatment necessary to monitor patterns of peripheral blood and functional state of the liver and kidneys. In violation of renal and hepatic function  need to decrease the dose and careful medical supervision.
If necessary, the definition of primobolan dosage steroids drug should be discontinued 48 hours before the test.
Avoid taking alcoholic drinks!
With the development of violations the organs of vision should consult an ophthalmologist.
In the period of treatment must be careful when driving vehicles and occupation of other potentially hazardous activities that require high concentration and psychomotor speed reactions.

 

Product form:

Valium for drug of a solution for intramuscular injection. At 100 mg drug in vials of dark glass type 1 with rings to be broken off.
A solution of benzyl primobolan dosage (solvent). 2.5 ml colorless glass vials of neutral glass of type 1 with rings to be broken off.
At 6 lyophilisate ampoules and vials with the solvent 6 for intramuscular administration of 2.5 ml, packed in a one or two plastic pallet, together with instructions for use in carton.

 

5942

primobolan side effects

In intramuscular a time to maximum plasma concentration is 15-30 minutes. Bioavailability – 90%. Associated primobolan side effects with the plasma protein by 99%. The equilibrium concentration in plasma is achieved at 24 hours after initiation of regular use. Therapeutic concentrations in the synovial fluid is maintained for 6-8 hours. It is metabolized in the liver by glyukuronirovaniya. It is shown mainly by the kidneys and intestines by 1-8%. The half-life is 1.6 – 1.9 hours, not accumulates..

 

Indications for use:

Short-term symptomatic treatment of acute pain in inflammatory processes of various origins: osteoarthritis, ankylosing spondylitis, gouty arthritis, acute gout, rheumatoid arthritis, psoriatic arthritis; bursitis, tenosynovitis; sciatica, myalgia, neuralgia, dorsalgia, sciatica; injuries and muscle strain; adnexitis, otitis media;headache and toothache; pain syndrome in oncology; post-traumatic and postoperative pain; algomenorrhea.

 

Contraindications:

 

  • individual hypersensitivity to ketoprofen, aspirin (including specifying a history of bronchospasm, urticaria or rhinitis caused by the intake of acetylsalicylic acid);
  • gastrointestinal disease in the acute phase;
  • gastrointestinal bleeding and perforation in history;
  • The expressed disturbances of function of kidneys and liver;
  • blood disorders (leucopenia, thrombocytopenia, blood coagulation disorders, hemophilia);
  • relief of pain immediately before or immediately after surgical treatment of cardiovascular system;
  • severe heart failure;
  • pregnancy and lactation;
  • children’s age (18 years).Precautions:
    Caution is advised to use the drug in patients: with impaired liver and / or kidney disease, gastrointestinal diseases in history; asthma, rhinitis, urticaria, polyps of the nasal mucosa; hypertension and / or cardiovascular disease, cerebrovascular disease; blood diseases, anemia; alcoholism, alcoholic liver cirrhosis, hyperbilirubinemia, diabetes, dehydration, smoking, sepsis, and in older patients. 

    Dosage and administration:

    The lyophilizate is dissolved attached solvent and the resulting solution was injected deep into the muscle. Intramuscular injection is indicated for the relief of acute pain, 100 mg 1-2 times a day. Duration of the parenteral treatment usually short-lived and is several days. After reaching the desired effect to the patient is prescribed capsules or suppositories.
    The maximum daily dose should not exceed 300 mg.

    Side effects:
    From the digestive system: primobolan side effects, abdominal pain, dyspepsia (nausea, vomiting, heartburn, flatulence, loss of appetite, diarrhea), stomatitis; change in taste, ulceration, and perforation of the mucous membrane of the gastrointestinal tract, gingival, gastrointestinal, hemorrhoidal bleeding; increased activity of “liver” transaminases serum hepatitis.
    Nervous system: headache, dizziness, insomnia, agitation, nervousness, somnolence, depression, fatigue, confusion or loss of consciousness, forgetfulness, migraines, peripheral neuropathy.
    From the senses : noise or ringing in the ears, blurred vision, conjunctivitis, mucosal dryness of the eye, eye pain, conjunctival hyperemia, hearing loss, vertigo.
    cardio-vascular system: increased blood pressure, tachycardia.
    From the side of hematopoiesis: rarely – agranulocytosis , anemia, hemolytic anemia, thrombocytopenia, leukopenia.
    From the urinary system: edema syndrome, cystitis, urethritis, renal failure, interstitial nephritis, nephrotic syndrome, hematuria.
    On the part of the respiratory system: dyspnea, bronchospasm, rhinitis, laryngeal edema, epistaxis , coughing up blood, shortness of breath.
    With the skin: alopecia, eczema, erythema multiforme exudative, including Stevens-Johnson syndrome, toxic epidermal necrolysis (Lyell’s syndrome), fotodermatit.
    Allergic reactions: skin rash (including erythematous, urticaria), itching, angioedema, exfoliative dermatitis, anaphylactic shock.
    Other: increased primobolan side effects sweating, myalgia, muscle twitching, thirst, vaginal bleeding, pain and redness at the injection site.

     

    Overdose:

    Symptoms: may cause drowsiness, nausea, vomiting, abdominal pain, bleeding, liver dysfunction and kidneys.
    Treatment is symptomatic: There is no specific antidote.

     

primobolan results

Approximately 20% of applied dose of metronidazole  was subjected to systemic absorption, resulting in drug concentration in plasma is approximately 12% of that after oral administration of a single dose of 0.5 The primobolan results (elimination set when administered systemically at normal liver function) is 8-10 hours.Communication with plasma proteins – less than 20%.

Indications
Topical treatment vaginitis and nonspecific.
Prevention of occurrence of anaerobic infections in surgical interventions on the abdominal and pelvic organs.

Contraindications

 

  • Hypersensitivity to imidazoles and nitroimidazole derivatives;
  • organic  (including epilepsy);
  • incoordination;
  • blood diseases (including leukopenia history);
  • hepatic insufficiency (in the case of the appointment of high doses);
  • pregnancy;
  • breast-feeding.Dosing and Administration
    The drug is only used in adults. Adults
  • Trichomonas vaginitis: one suppository daily, in the vagina for 10 days in combination with taking metronidazole formulation into tablets.
  • Nonspecific vaginitis: 1 suppository 2 times a day for 7 days, optionally in combination with metronidazole reception formulation into tablets. Be sure to simultaneous treatment of sexual partner drug metronidazole, no matter if they have any symptoms of the disease.
    Treatment with metronidazole should not be appointed for more than 10 days, and recur more often primobolan results than 2-3 times a year.
    Pre-releasing suppository by using a contour packaging scissors to cut the tape along the contour of a suppository and put it deep into the vagina.Side effect On the part of the gastrointestinal tract: nausea, a metallic taste in the mouth, dry mouth, decreased appetite, glossitis, stomatitis, pancreatitis, anorexia, epigastric pain, vomiting, diarrhea, constipation. From the nervous system: headache, dizziness , incoordination, ataxia, confusion, irritability, depression, irritability, fatigue, insomnia, seizures, confusion, hallucinations, peripheral neuropathy (especially long-term use). Allergic reactions: urticaria, skin rash, redness of the skin, nasal congestion , fever, arthralgia. from the mochevydelitelyyuy system: dysuria, polyuria, cystitis, urinary incontinence, candidiasis, possibly staining of urine brownish-reddish color. Local reactions: burning sensation or irritation of the penis in the sexual partner, a burning sensation or frequent urination, vulvitis (itching, burning pain, or redness of the mucous membrane in the external genitalia). Other: neutropenia, leukopenia, flattening of the T wave on the ECG. After discontinuation of the drug may develop vaginal candidiasis.

     

    Interaction with other drugs
    similar disulfiram causes intolerance of ethanol.
    Concomitant use with disulfiram may lead to the development of a variety of neurological symptoms (interval between administration – not less than 2 weeks). It enhances the effect of indirect anticoagulants, which leads to an increase in the time of formation of prothrombin.
    When concomitantly with drugs lithium may increase the concentration of the latter in plasma.
    When concomitantly with cyclosporine may increase the concentration of the latter in plasma.
    Cimetidine inhibits the metabolism of metronidazole, which may lead to an increase in its concentration serum and an increased risk of side effects. Simultaneous administration of drugs that stimulate the microsomal oxidation enzymes in the liver (phenobarbital, phenytoin), elimination can yckoryat metronidazole, whereby its concentration decreases in plasma. Metronidazole reduces the clearance , resulting in an increase of its toxicity. Metronidazole increases the level of busulfan in plasma, resulting in an increase of its toxicity (severe).
    Do not combine with non-depolarizing muscle relaxants (vecuronium bromide).

    Cautions
    Since the simultaneous reception of alcohol-drug can have an effect similar to disulfiram (burning sensation, vomiting, tachycardia), should warn patients that during treatment flagyl should not drink alcoholic beverages or medicines containing alcohol.
    Long-term administration of the drug, it is desirable be under the control of blood formula. When leukopenia opportunity to continue treatment depends on the risk of infection.
    In the treatment of Trichomonas vaginitis in women should refrain from sexual activity. Be sure to simultaneous treatment of sexual partners. Treatment does not stop at the time of menstruation. After primobolan results treatment of trichomoniasis should conduct pilot tests for 3 successive cycles before and after menstruation.
    It should stop treatment with the appearance of ataxia, dizziness, hallucinations development, with a deterioration in neurological status of the patients. It will be appreciated that Metronidazole may immobilize Treponema, which leads to false positive test Nelson.

    Effects on ability to drive and use other mechanisms
    in connection with the possibility of dizziness and other side effects associated with the reception of the drug are advised to refrain from driving and other mechanisms.

 

methenolone enanthate

With disulfiramom reported on the development of psychotic reactions in patients treated with both metronidazole and disulfiram (the interval between administration of metronidazole should be at least 2 weeks). With ethanol may experience difulfiramopodobnyh reactions (redness of the skin, vomiting, tachycardia). with indirect anticoagulants (warfarin)Strengthening of the anticoagulant effect and increase the hemorrhagic risk associated with a slowing of their hepatic metabolism, which can lead to an increase in prothrombin time. In the event of simultaneous applications require more frequent monitoring of prothrombin time and, if necessary, dose adjustment of anticoagulants.

With methenolone enanthate lithium preparations , when taken concomitantly with metronidazole drugs lithium may increase the concentration of the latter in the blood plasma. In an application should be monitored plasma concentrations of lithium, creatinine and electrolytes. With cyclosporine At simultaneous reception of metronidazole with cyclosporine may increase the serum concentration of cyclosporine. If necessary, the simultaneous use of these two metronidazole requires monitoring serum cyclosporine and creatinine. With cimetidine, cimetidine inhibits metabolism metronidazole, which may lead to an increase in its concentration in the serum and an increased risk of side effects. Since drugs that induce enzymes of microsomal oxidation in the liver (phenobarbital, phenytoin) Simultaneous administration of metronidazole with drugs stimulating enzymes microsomal oxidation in the liver (phenobarbital, phenytoin) may accelerate the elimination of metronidazole, thereby reducing its concentration in plasma. with fluorouracil metronidazole reduces clearance fluorouracil, resulting in increased toxicity. since busulfan metronidazole increases the concentration of busulfan in the plasma, which may lead to the development of severe toxic effect of busulfan. with the non-depolarizing muscle relaxants (vecuronium bromide) is not recommended to be combined with non-depolarizing muscle relaxants (vecuronium bromide). Sulfonamide enhance the antimicrobial action of metronidazole.

 

Precautions for use of the drug
As the concomitant use of metronidazole with alcohol can have an effect similar to disulfiram (burning sensation, vomiting, tachycardia), should warn patients that during Flagyl drug methenolone enanthate should not drink alcohol or medicines that contain alcohol .
it is necessary to carefully weigh the evidence for long-term use of the drug and without strict indications avoid its prolonged use. Where there are strict indications preparation is applied over a long time, what is usually recommended, treatment should be under the control of haematological parameters and side reactions such as peripheral or central neuropathy (paresthesias, ataxia, dizziness, convulsions), when they appear, treatment should be discontinued .
in the treatment  vaginitis in womenurethritis in men should refrain from sexual activity. Be sure to simultaneous treatment of sexual partners. Treatment does not stop at the time of menstruation. After treatment of trichomoniasis should conduct pilot tests for 3 successive cycles before and after menstruation.
It is necessary to take into account may immobilize , which leads to false positive test Nelson.

Effects on ability to drive and occupation of other potentially hazardous activities
Taking methenolone enanthate into account the profile of side effects (dizziness, blurred vision, etc.) are advised to refrain from driving, lessons from other potentially hazardous activities that require high concentration and psychomotor speed reactions.