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primobolan results

Approximately 20% of applied dose of metronidazole  was subjected to systemic absorption, resulting in drug concentration in plasma is approximately 12% of that after oral administration of a single dose of 0.5 The primobolan results (elimination set when administered systemically at normal liver function) is 8-10 hours.Communication with plasma proteins – less than 20%.

Indications
Topical treatment vaginitis and nonspecific.
Prevention of occurrence of anaerobic infections in surgical interventions on the abdominal and pelvic organs.

Contraindications

 

  • Hypersensitivity to imidazoles and nitroimidazole derivatives;
  • organic  (including epilepsy);
  • incoordination;
  • blood diseases (including leukopenia history);
  • hepatic insufficiency (in the case of the appointment of high doses);
  • pregnancy;
  • breast-feeding.Dosing and Administration
    The drug is only used in adults. Adults
  • Trichomonas vaginitis: one suppository daily, in the vagina for 10 days in combination with taking metronidazole formulation into tablets.
  • Nonspecific vaginitis: 1 suppository 2 times a day for 7 days, optionally in combination with metronidazole reception formulation into tablets. Be sure to simultaneous treatment of sexual partner drug metronidazole, no matter if they have any symptoms of the disease.
    Treatment with metronidazole should not be appointed for more than 10 days, and recur more often primobolan results than 2-3 times a year.
    Pre-releasing suppository by using a contour packaging scissors to cut the tape along the contour of a suppository and put it deep into the vagina.Side effect On the part of the gastrointestinal tract: nausea, a metallic taste in the mouth, dry mouth, decreased appetite, glossitis, stomatitis, pancreatitis, anorexia, epigastric pain, vomiting, diarrhea, constipation. From the nervous system: headache, dizziness , incoordination, ataxia, confusion, irritability, depression, irritability, fatigue, insomnia, seizures, confusion, hallucinations, peripheral neuropathy (especially long-term use). Allergic reactions: urticaria, skin rash, redness of the skin, nasal congestion , fever, arthralgia. from the mochevydelitelyyuy system: dysuria, polyuria, cystitis, urinary incontinence, candidiasis, possibly staining of urine brownish-reddish color. Local reactions: burning sensation or irritation of the penis in the sexual partner, a burning sensation or frequent urination, vulvitis (itching, burning pain, or redness of the mucous membrane in the external genitalia). Other: neutropenia, leukopenia, flattening of the T wave on the ECG. After discontinuation of the drug may develop vaginal candidiasis.

     

    Interaction with other drugs
    similar disulfiram causes intolerance of ethanol.
    Concomitant use with disulfiram may lead to the development of a variety of neurological symptoms (interval between administration – not less than 2 weeks). It enhances the effect of indirect anticoagulants, which leads to an increase in the time of formation of prothrombin.
    When concomitantly with drugs lithium may increase the concentration of the latter in plasma.
    When concomitantly with cyclosporine may increase the concentration of the latter in plasma.
    Cimetidine inhibits the metabolism of metronidazole, which may lead to an increase in its concentration serum and an increased risk of side effects. Simultaneous administration of drugs that stimulate the microsomal oxidation enzymes in the liver (phenobarbital, phenytoin), elimination can yckoryat metronidazole, whereby its concentration decreases in plasma. Metronidazole reduces the clearance , resulting in an increase of its toxicity. Metronidazole increases the level of busulfan in plasma, resulting in an increase of its toxicity (severe).
    Do not combine with non-depolarizing muscle relaxants (vecuronium bromide).

    Cautions
    Since the simultaneous reception of alcohol-drug can have an effect similar to disulfiram (burning sensation, vomiting, tachycardia), should warn patients that during treatment flagyl should not drink alcoholic beverages or medicines containing alcohol.
    Long-term administration of the drug, it is desirable be under the control of blood formula. When leukopenia opportunity to continue treatment depends on the risk of infection.
    In the treatment of Trichomonas vaginitis in women should refrain from sexual activity. Be sure to simultaneous treatment of sexual partners. Treatment does not stop at the time of menstruation. After primobolan results treatment of trichomoniasis should conduct pilot tests for 3 successive cycles before and after menstruation.
    It should stop treatment with the appearance of ataxia, dizziness, hallucinations development, with a deterioration in neurological status of the patients. It will be appreciated that Metronidazole may immobilize Treponema, which leads to false positive test Nelson.

    Effects on ability to drive and use other mechanisms
    in connection with the possibility of dizziness and other side effects associated with the reception of the drug are advised to refrain from driving and other mechanisms.

 

methenolone enanthate

With disulfiramom reported on the development of psychotic reactions in patients treated with both metronidazole and disulfiram (the interval between administration of metronidazole should be at least 2 weeks). With ethanol may experience difulfiramopodobnyh reactions (redness of the skin, vomiting, tachycardia). with indirect anticoagulants (warfarin)Strengthening of the anticoagulant effect and increase the hemorrhagic risk associated with a slowing of their hepatic metabolism, which can lead to an increase in prothrombin time. In the event of simultaneous applications require more frequent monitoring of prothrombin time and, if necessary, dose adjustment of anticoagulants.

With methenolone enanthate lithium preparations , when taken concomitantly with metronidazole drugs lithium may increase the concentration of the latter in the blood plasma. In an application should be monitored plasma concentrations of lithium, creatinine and electrolytes. With cyclosporine At simultaneous reception of metronidazole with cyclosporine may increase the serum concentration of cyclosporine. If necessary, the simultaneous use of these two metronidazole requires monitoring serum cyclosporine and creatinine. With cimetidine, cimetidine inhibits metabolism metronidazole, which may lead to an increase in its concentration in the serum and an increased risk of side effects. Since drugs that induce enzymes of microsomal oxidation in the liver (phenobarbital, phenytoin) Simultaneous administration of metronidazole with drugs stimulating enzymes microsomal oxidation in the liver (phenobarbital, phenytoin) may accelerate the elimination of metronidazole, thereby reducing its concentration in plasma. with fluorouracil metronidazole reduces clearance fluorouracil, resulting in increased toxicity. since busulfan metronidazole increases the concentration of busulfan in the plasma, which may lead to the development of severe toxic effect of busulfan. with the non-depolarizing muscle relaxants (vecuronium bromide) is not recommended to be combined with non-depolarizing muscle relaxants (vecuronium bromide). Sulfonamide enhance the antimicrobial action of metronidazole.

 

Precautions for use of the drug
As the concomitant use of metronidazole with alcohol can have an effect similar to disulfiram (burning sensation, vomiting, tachycardia), should warn patients that during Flagyl drug methenolone enanthate should not drink alcohol or medicines that contain alcohol .
it is necessary to carefully weigh the evidence for long-term use of the drug and without strict indications avoid its prolonged use. Where there are strict indications preparation is applied over a long time, what is usually recommended, treatment should be under the control of haematological parameters and side reactions such as peripheral or central neuropathy (paresthesias, ataxia, dizziness, convulsions), when they appear, treatment should be discontinued .
in the treatment  vaginitis in womenurethritis in men should refrain from sexual activity. Be sure to simultaneous treatment of sexual partners. Treatment does not stop at the time of menstruation. After treatment of trichomoniasis should conduct pilot tests for 3 successive cycles before and after menstruation.
It is necessary to take into account may immobilize , which leads to false positive test Nelson.

Effects on ability to drive and occupation of other potentially hazardous activities
Taking methenolone enanthate into account the profile of side effects (dizziness, blurred vision, etc.) are advised to refrain from driving, lessons from other potentially hazardous activities that require high concentration and psychomotor speed reactions.

 

primobolan cycle

When administered Metronidazole is rapidly and almost completely absorbed (about 80% for 1 hour). Food does not affect the absorption of metronidazole. The bioavailability of not less than 80%. After oral administration of 500 mg of metronidazole over the plasma concentrationl. The  contact with blood proteins insignificant and does not exceed 10-20%). Metronidazole rapidly penetrates into tissues (lung, kidney, liver, skin, bile, spinal fluid, saliva, semen, vaginal secretions) in breast milk and pass the placental barrier. Metabolized about 30-60% metronidazole by hydroxylation, oxidation and glyukuronirovaniya. The major metabolite (2-oximetronidazole) also has protivoprotozoynoe and antimicrobial effects.
Withdrawal of metronidazole is carried primobolan cycle by 40-70% through the kidneys (unchanged – about 35% of the dose). In patients with impaired renal function at course taking metronidazole may increase its concentration in the blood serum.

Indications

 

  • Protozoal infections: extra-intestinal amebiasis, including amebic liver abscess, intestinal amebiasis (amebic dysentery), trichomoniasis (including).
  • Infections caused of Bacteroides spp, bone and joint infections, central nervous system infections , including meningitis , brain abscess, bacterial endocarditis and pneumonia, empyema and lung abscess, sepsis.
  • Infections caused by species of Clostridium spp, Peptococcu niger and spp Peptostreptococcus.. : Abdominal infections (peritonitis, liver abscess), pelvic infections (endometritis, abscess of the fallopian tubes and ovaries, vaginal cuff infection).
  • Pseudomembranous colitis (involving the use of antibiotics).
  • Gastritis or ulcer 12 duodenal ulcer associated with of Helicobacter pylori (complex therapy).
  • Prevention of postoperative complications (especially interventions on the colon, adrectal area apendektomiya, gynecological operations).Contraindications
  • Hypersensitivity to imidazoles and nitroimidazole derivatives.
  • Organic CNS (including epilepsy).
  • Leukopenia (including history).
  • Liver failure (in the case of the appointment of large doses).
  • Pregnancy.
  • Lactation.
  • Children under 10 years old.Carefully:
  • Hepatic encephalopathy.
  • Acute and chronic diseases of the peripheral and central nervous system (risk of worsening of neurological symptoms).
  • Renal insufficiency.Dosage and administration
    Metronidazole is intended for oral administration, either before or after a meal. Wash down with plenty of water.
    When the intestinal amebiasis primobolan cycle used within 7 days of 1500 mg per day for three meals. In acute amoebic dysentery – a daily dose of 2250 mg, divided into three stages. Children from 10 to 15 years – 500 mg per day, divided into 2 doses.
    If an abscess of the liver and other extra-intestinal forms of amebiasis maximum daily dose is 2,500 mg, divided into 3 doses for 3-5 days, in combination with antibiotics and tetracycline other therapies. . Children from 10 to 15 years – 500 mg per day, divided into 2 doses
    If trichomoniasis in women (urethritis and vaginitis) administered a single dose of 2 g or as a course of treatment for 10 days: 1 tablet. (250 mg), 2 times a day.
    If trichomoniasis in men (urethritis)  administered once at a dose of 2 g or a course of treatment for 10 days on 1 tab. (250 mg), 2 times a day.
    Treatment of anaerobic infections usually start with an intravenous infusion, followed by a transition to the tablet. For adults, the is 500 mg three times a day. The duration of treatment is up to 7 days.
    For the treatment of pseudomembranous colitis is prescribed (Table 2.) 3-4 times a day. Duration of treatment is determined by your doctor.
    For primobolan cycle pylori eradication appoint  daily in combination therapy (eg, amoxicillin).
    For the prevention of postoperative complications appoint 750-1500 mg per day in 3 divided doses for 3-4 of the day before surgery. After 1-2 days after the operation (when the reception is already enabled orally) per day for 7 days.Possible side effects when using the drug Violations of the gastrointestinal tract
  • Epigastric pain, nausea, vomiting, diarrhea.
  • Inflammation of the oral mucosa (glossitis, stomatitis), dysgeusia ( “metallic” taste in the mouth), loss of appetite, anorexia, dryness of the oral mucosa, constipation.
  • Pancreatitis (cases of reversible). Violations of the immune system
  • Angioedema, anaphylactic shock. Disorders of the nervous system
  • Peripheral sensory neuropathy.
  • Headache, convulsions, dizziness.
  • Reported the development of encephalopathy (eg confusion) and subacute cerebellar syndrome (impaired coordination and synergy of movements, ataxia, dysarthria, gait disturbance, nystagmus and tremor) which regress after the abolition of metronidazole.
  • Aseptic meningitis. Mental Disorders
  • Psychotic disorders including confusion, hallucinations.
  • Depression, insomnia, irritability, anxiety. Violations of the organ of vision
  • Transient visual disturbances, such as double vision, myopia. Violations of the blood and lymphatic system
  • Agranulocytosis, leukopenia, neutropenia, and thrombocytopenia. Violations of the liver and biliary tract
  • It reported on the development of reversible disorders in laboratory parameters of liver function and cholestatic hepatitis sometimes with jaundice. Violations of the skin and subcutaneous tissue
  • Rash, pruritus, flushing of the skin, urticaria.
  • Pustular rash. Violations of the kidney and urinary tract
  • Perhaps urine staining primobolan cycle reddish brown color due to the presence of water-soluble metabolite in the urine of metronidazole.
  • Dysuria, polyuria, cystitis, urinary incontinence, candidiasis. General disorders and administration site in
  • Fever, stuffy nose, arthralgia, weakness. Laboratory and instrumental data.

primo steroid

Ambroxol is the active l metabolite of bromhexine. It has sekretomotornym, sekretoliticheskim and expectorant action. It stimulates serous cells of glands of bronchial mucosa by increasing mucin content and thus changes the disturbed ratio of serous and mucous components of phlegm. Ambroxol content increases mucous secretion and release of surfactant (surfactant) in the alveoli and primo steroid bronchi. Increases motor activity of ciliated epithelium, increases mucociliary phlegm transport. On average, orally effect occurs within 30 minutes, the duration – 6-12 hours.

 

After ingestion ambroxol rapidly and almost completely absorbed from the gastrointestinal tract. The maximum plasma concentration (C max ) is achieved after approximately 1-3 hours. The resulting metabolites (such as dibromantranilovaya acid glucuronide) excreted by the kidneys. Distribution . Binding to plasma proteins – about 85% (80-90%). Ambroxol penetrates through the blood-brain and placental barriers and is excreted in breast milk. Metabolism . Ambroxol is metabolized in the liver by conjugation to form a pharmacologically inactive metabolites. Excretion . Because of the high degree of binding to plasma proteins and large distribution volume, and slow reverse distribution of tissue elimination significantly ambroxol blood by dialysis or forced diuresis not be expected.

 

Indications
Acute and chronic diseases of the respiratory tract, accompanied by violation of the secretion and transport of sputum:

  • acute and chronic bronchitis;
  • pneumonia;
  • chronic obstructive pulmonary disease;
  • bronchial asthma with obstruction of primo steroid sputum discharge;
  • bronchiectasis.

Contraindications

  • Hypersensitivity to ambroxol or other components of the preparation.
  • Children up to age 6 years.

Precautions :

  • dysmotility bronchi and formation of secretions in large quantities (for example, a rare syndrome of fixed cilia);
  • renal failure or hepatic insufficiency;
  • peptic ulcer and 12 duodenal ulcer.

Pregnancy and lactation
Use of the drug in the I trimester of pregnancy is contraindicated. In II and III trimester of pregnancy, the drug should be taken with caution.
Use of the drug during lactation is possible only if the expected benefit of treatment to the mother outweighs the potential risk to the infant.

Dosage and administration:
Tablets for oral use.
Tablets are taken after a meal, without chewing and drinking plenty of fluids. It is recommended to observe the following dosages: Children aged 6 to 12 years old : 2-3 times daily 1/2 tablet (respectively, 2-3 times 15 mg of ambroxol hydrochloride). Adults and children over 12 years : during the first 2- 3 days, take 3 times a day 1 tablet (respectively, 3 times 30 mg of ambroxol hydrochloride), then – 2 times a day 1 tablet (or 2 x 30 mg of ambroxol hydrochloride). If necessary for enhancing the therapeutic effect can be given 2 tablets 2 times a day (corresponding to 120 mg ambroxol hydrochloride / day). In renal failure, or severe liver disease should increase the interval between doses, or reduce the dose while taking the drug. The duration of the application is installed on an individual basis depending on the evidence and the disease. Without a doctor’s primo steroid appointment should not take more than 4-5 days.

 

Side effects
Possible side effects are listed below in descending frequency of occurrence: Sometimes  including isolated reports. Allergic reactions : sometimes – skin rash, urticaria, angioedema edema, pyrexia, dyspnea; very rarely – anaphylactic shock. From the digestive system : sometimes – diarrhea, dry mouth, constipation; long-term use – abdominal pain, nausea, vomiting. For the skin : very rarely – toxic epidermal necrolysis, Stevens-Johnson syndrome. Other : rarely – weakness, headache, rash, dysuria.

Overdose
Symptoms of a person overdose have not been described.
There are: short-term anxiety, diarrhea, nausea, vomiting.
If a significant excess of the dose (more than 25 mg / kg / day) may decrease blood pressure, excessive salivation. Treatment : artificial vomiting, gastric lavage in the first 1 -2 hours after ingestion;reception of fat-containing products; symptomatic therapy.

Interaction with other drugs
the combined use ambroxol and antitussive drugs that suppress the cough reflex, due to the weakening of the cough reflex may be a risk of stagnation in the bronchi. Increases penetration in bronchial secretion of amoxicillin, cefuroxime, erythromycin and doxycycline.

Cautions
Patients with severe renal insufficiency primo steroid should take into account the possibility of cumulation of ambroxol metabolites formed in the liver.
Necessary to ensure entry to the body fluid in sufficient quantity to maintain sekretoliticheskim action Ambroxol during ingestion.

methenolone acetate

Combined medication of plant origin; due to the pharmacological activity of biologically active substances complex in its composition.

Valerian extract has a moderate, sedative and antispasmodic action.

Hawthorn extract has methenolone acetate mild cardiotonic, antispasmodic, sedative effect.

 

INDICATIONS:

As a sedative with increased nervous irritability, insomnia, as well as in the treatment of functional disorders of cardiac activity, false angina, asthenic-neurotic conditions.

 

CONTRAINDICATIONS:

Hypersensitivity to the drug, children’s age (up to 18 years, due to the lack of clinical data).

 

Pregnancy and lactation:

In the absence so far of adequate studies the drug is not recommended for use during pregnancy and breastfeeding.

 

DOSAGE AND ADMINISTRATION:

Taking into adults, not liquid, squeezed small amounts of water, 1-2 tablets 2-3 times a day.

When insomnia take 2 tablets 30-60 minutes before bedtime.

The course of treatment methenolone acetate 1,5-2 months.

 

SIDE EFFECTS:

Allergic reactions (urticaria, pruritus). With prolonged use at doses higher than recommended, there may be lethargy, depression, drowsiness, decreased performance.

 

OVERDOSE:

When possible overdose fatigue, abdominal pain, chest tightness, dizziness, tremor, mydriasis, bradycardia, decreased blood pressure.

 

INTERACTION WITH OTHER DRUGS:

The drug increases the effects of hypnotics, sedatives, tranquilizers and other drugs which depress the central nervous system, antispasmodic, and ethanol that require dose adjustment when used together.

The combined use of the drug and cardiac glycosides (strofantin, digoxin and others.) Is amplified cardiac effect.

 

SPECIAL INSTRUCTIONS:

Do not use the drug more than 1,5-2 months on a daily basis.

In applying the drug may methenolone acetate reduce the speed of psychomotor reactions, so it should not be used to control a vehicle or operating machinery.